Rediscover
the value
With autologous, viable cells and regenerative nature, drilled bone dust can be a valuable adjunct to other bone growth agents. Learn more about just some of the data reflecting its osteogenic, osteoinductive and osteoconductive potential.1-6
Viability
Human spinal bone dust as a potential local autograft
Isolation of mesenchymal stem cells from bone marrow wastes of spinal fusion procedure (TLI…
Improved autologous cortical bone harvest and viability with 2Flute otologic burs
Histologic evaluation of high speed burr shavings collected during spinal decompression surgery
Contains viable1-6
- Osteoblasts
- Osteoclasts
- Osteocytes
- Osteoprogenitor/mesenchymal stem cells
- Osteoblast expression markers
Osteoblast related genes from adherent cells from bone pate fragments2
Photomicrograph of local autograft demonstrating the presence of viable osteocytes4
Viable bone-forming cells, even after drilling1-6
"The bone shavings appear to remain viable after burring, as there was no microscopic evidence of damage to the cells."5
"Osteocytes are able to remain viable after drilling."2
"Bone dust samples…were sent to our local pathology lab where the presence of viable osteocytes was confirmed."4
Growth
Use of the solis cage and local autologous bone graft for anterior cervical discectomy and fusion: early technical experience
Improved autologous cortical bone harvest and viability with 2Flute otologic burs
Isolation of mesenchymal stem cells from bone marrow wastes of spinal fusion procedure (TLI…
Exhibits ALP activity, collagen synthesis and calcium deposition3
ALP stain
Collagen stain
Calcium stain
Activity
Comparison of osteogenic potential of calvarial bone dust, bone fragments, and periosteum
Human spinal bone dust as a potential local autograft
Isolation of mesenchymal stem cells from bone marrow wastes of spinal fusion procedure (TLI…
100% progressive new bone formation4
when using bone dust with a cervical interbody cage
Upregulates factors involved in bone cell recruitment, maturation, healing and remodeling
(IL-6, IL-11, MCP-1, IBSP, VEGF, OPG, RANKL)1
Releases cytokines and growth factors with known anabolic effects on bone healing
(IL-1ß, IL-6, TGF-ß, VEGF, FGF-Basic, PDFG-BB)1
7-fold increase in osteoblast proliferation1
Primary human osteoblast proliferation increase in response to bone dust. *P<0.05
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- Gao, R. et al. (2018) Human Spinal Bone Dust as a Potential Local Autograft. Spine, 43.4.
- Roth, A. et al. (2017) Improved Autologous Cortical Bone Harvest and Viability With 2Flute Otologic Burs. The Laryngoscope.
- Gupta, A. et al. (2009) Comparison of Osteogenic Potential of Calvarial Bone Dust, Bone Fragments, and Periosteum. The Journal of Craniofacial Surgery.
- Shad, A. et al. (2005) Use of the Solis cage and local autologous bone graft for anterior cervical discectomy and fusion: early technical experience. Journal of Neurosurgery Spine.
- Patel, V. et al. (2009) Histologic Evaluation of High Speed Burr Shavings Collected During Spinal Decompression Surgery.
- Ichiyanagi, T. et al. (2010) Isolation of mesenchymal stem cells from bone marrow wastes of spinal fusion procedure (TLIF) for low back pain patients and preparation of bone dusts for transplantable autologous bone graft with a serum glue. BioScience Trends.
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